Hybrid Approach for Automatic Drug Dispensing and Control

Abstract

Clinical scenario for critically ill patients involves large number of medical devices, such as, bed side monitors that provide vital information about the admitted patient. Critically ill patients need prompt and perfect decision, so that lifesaving drugs can be delivered at a proper time. Moreover suggestions/ recommendations of a super specialist doctor may also be required in hospitals. The main problem in hospitals is lack of specialist doctors, so, patients are not able to approach to them on time. Automatic drug delivery using microprocessor/ microcontroller has improved tremendously in recent years due to advancement in Information and Communication Technology (ICT). This paper is focused on various Drug Delivery System Interfaces used in emergency cases to reduce manual intervention. We are proposing a hybrid approach for drug dispensing, which can work as open or closed loop system. Another feature of this system is that it can be controlled from a remote location, so is to provide virtual presence of a doctor. The system will help the doctor monitor the patient as per the immediate requirement and deliver drug remotely to patient using smart phone.

  • Page Number : 69-77

  • Keywords
    Automatic Drug delivery, Infusion pump, Open Loop, Closed Loop, Depth of Anaesthesia, BIS

  • DOI Number
    https://doi.org/10.15415/jmrh.2017.32007

  • Authors
    Naveen Kumar, S.N.Panda, Preethi Pradhan

References

  • Simanski, O., Schubert, A., Kaehler, R., Janda, M., Bajorat, J., Hofmockel, R. and Lampe, B., 2007, June. Automatic drug delivery in anaesthesia: From the beginning until now. In Control & Automation, 2007. MED’07. Mediterranean Conference on (pp. 1-6). IEEE.
  • Ziv, Stephen D. Small, Paul Root Wo, A. (2000). Patient safety and simulation based medical education. Med Teach, 22(5), pp.489–495. https://doi.org/10.1080/01421590050110777 Arney, D., Pajic, M., Goldman, J.M., Lee, I., Mangharam, R. and Sokolsky, O., 2010, April. Toward patient safety in closed-loop medical device systems. In Proceedings of the 1st ACM/IEEE International Conference on Cyber-Physical Systems (pp. 139–148). ACM https://doi.org/10.1145/1795194.1795214
  • Huang, J., Ying-Ying Lu, Nayak, A. and Roy, R. (1999). Depth of anaesthesia estimation and control [using auditory evoked potentials]. IEEE Transactions on Biomedical Engineering, 46(1), pp.71–81. https://doi.org/10.1109/10.736759
  • Kameneva, Tatiana et al. ‘A Comparison of Open-Loop And Closed-Loop Stimulation Strategies To Control Excitation Of Retinal Ganglion Cells’. Biomedical Signal Processing and Control 14 (2014): 164–174. Web. https://doi.org/10.1016/j.bspc.2014.07.015
  • Dumont, Guy A., and J. Mark Ansermino. ‘Closed-Loop Control of Anesthesia: A Primer for Anesthesiologists’. Anesthesia & Analgesia 117.5 (2013): 1130– 1138. Web. https://doi.org/10.1213/ANE.0b013e3182973687
  •  Hayakawa, T., Haddad, W.M., Bailey, J.M. and Hovakimyan, N. (2005) ‘Passivity-Based Neural Adaptive Output Feedback Control for Nonlinear Nonnegative Dynamical Systems’, IEEE Transaction on Neural Network, vol. 16, March, pp. 387–398. https://doi.org/10.1109/TNN.2004.841782
  •  Lin, H., Beck, C. and Bloom, M. (2004). On the Use of Multivariable Piecewise- Linear Models for Predicting Human Response to Anesthesia. IEEE Transactions on Biomedical Engineering, 51(11), pp.1876–1887. https://doi.org/10.1109/TBME.2004.831541
  • AGARWAL, J., PURI, G. and MATHEW, P. (2009). Comparison of closed loop vs. manual administration of propofol using the Bispectral index in cardiac surgery. Acta Anaesthesiologica Scandinavica, 53(3), pp.390–397. https://doi.org/10.1111/j.1399-6576.2008.01884.x
  • Struys, M., De Smet, T., Versichelen, L., Van de Velde, S., Van den Broecke, R. and Mortier, E. (2001). Comparison of Closed-loop Controlled Administration of Propofol Using Bispectral Index as the Controlled Variable versus “Standard Practice” Controlled Administration. Anesthesiology, 95(1), pp.6–17. https://doi.org/10.1097/00000542-200107000-00007
  • Soltesz, K., Dumont, G., van Heusden, K., Hagglund, T. and Ansermino, J.M., 2012, December. Simulated mid-ranging control of propofol and remifentanil using EEG-measured hypnotic depth of anaesthesia. In Decision and Control (CDC), 2012 IEEE 51st Annual Conference on (pp. 356-361). IEEE.
  • Meystre, S., 2005. The current state of telemonitoring: a comment on the literature. Telemedicine Journal & e-Health, 11(1), pp.63–69. https://doi.org/10.1089/tmj.2005.11.63
  • Fernandes, B., Afonso, J.A. and Simões, R., 2011, June. Vital signs monitoring and management using mobile devices. In 6th Iberian Conference on Information Systems and Technologies (CISTI 2011) (pp. 1-6). IEEE.
  •  Van Halteren, A.T., Bults, R.G.A., Wac, K.E., Konstantas, D., Widya, I.A., Dokovski, N.T., Koprinkov, G.T., Jones, V.M. and Herzog, R., 2004. Mobile patient monitoring: The mobihealth system.
  • Yuan, B. and Herbert, J., 2011, March. Web-based real-time remote monitoring for pervasive healthcare. In Pervasive Computing and Communications Workshops (PERCOM Workshops), 2011 IEEE International Conference on (pp. 625-629). IEEE. https://doi.org/10.1109/PERCOMW.2011.5766964

  • Published Date : 2017-04-10